PCOS, PCOS test, poly cystic ovarian syndrome

PCOS Diagnosis

Diagnosis and Investigation of PCOS

PCOS DIET | PCOS DIET AND FERTILITY | MANAGE | SYMPTOMS | TESTING | MEDICATIONS | FAQ

Why are so many cases of polycystic ovarian syndrome un diagnosed? This is largely Because the symptoms of PCOS can vary from woman to woman.

Diagnosis of PCOS is now largely based on the Rotterdam criteria, which are inclusive of the original National Institutes of Health (NIH) criteria and require two of three key features: anovulation, clinical hyperandrogenism and polycystic ovaries on ultrasound. However, using this diagnostic criteria does not account for variations in life stage, genotype, ethnicity and environmental factors, including lifestyle and body weight.

Diagnostic investigations should also exclude other causes and include thyroid function and uptake tests and prolactin and follicle-stimulating hormone (FSH) levels. For diagnosis, androgen levels should be measured; however, this remains controversial. Vaginal ultrasound is often needed for diagnosis where hyperandrogenism and anovulation are not both clearly present. Ultrasound can check for polycystic ovaries and endometrial thickness. However, vaginal ultrasound should be reserved for sexually active women. The role of ultrasound remains controversial for adolescents, among whom a polycystic appearance of the ovaries is very common, potentially leading to overdiagnosis.

Screening is also vital to detect PCOS complications and guide prevention and treatment. Comprehensive cardiovascular risk-factor screening, including family history, ethnic group, body mass index (BMI), waist circumference, smoking status, blood pressure, glycaemic status (oral glucose tolerance test [OGTT]) and lipid profile, is important at diagnosis and should be repeated with a frequency informed by metabolic risk (eg, body weight, age, family history, ethnicity). Optimal methodology for the routine screening for prediabetes and DM2 has been controversial in PCOS, but because lifestyle change and glucose regulation techniques such as metformin, orthomolecular or herbal support improve insulin resistance in PCOS, these measures have been shown to dramatically reduce progression to diabetes.

Clinical features of PCOS

PCOS is a chronic condition manifesting over many years. Women with PCOS present with psychological, reproductive and metabolic implications. In terms of psychosocial implications, challenges to feminine identity and body image due to obesity, acne, excess hair, infertility and long-term health related concerns compromise quality of life and adversely affect mood and psychological wellbeing.

Reproductive and reproductive hormonal features are often the best recognised features in PCOS as they form the basis of the diagnostic criteria. These include clinical and biochemical hyperandrogenism, anovulation, subfertility and polycystic ovaries on ultrasound. A key point is that fertility is not necessarily impaired in all PCOS cases. Some women conceive without medical intervention, depending on the severity of the condition.

Metabolic features of PCOS include an apparent propensity for excess weight gain, an increased prevalence of prediabetes and DM2, a 5-10-fold risk of progression from prediabetes to DM2 and a 4-7-fold risk of DM2.

Cardiovascular risk factors are increased and CVD appears more prevalent among women with PCOS despite inadequate long-term studies to appropriately address this question. In the general population, Insulin Resistance is a predictor of CVD. Women with PCOS also have an increased prevalence of metabolic syndrome (associated with an increased risk for DM2 and CVD), individual risk factors for CVD and clinical signs of atherosclerosis, which are all exacerbated by obesity. Women with PCOS are therefore a population at high risk of developing DM2 and CVD.

Obesity or excess weight is a major cause of chronic disease in Western countries. Recent data from the Australian Longitudinal Study on Women's Health showed that among 26-31 year old women, 20.4% were overweight and a further 13.9% were obese. Overall, the proportion of adults who are obese has doubled in the past 20 years.

Obesity is now the primary cause of chronic disease among Australian women, with adverse outcomes including DM2 and CVD. Obesity has a specific impact on female reproductive health, increasing the prevalence and severity of PCOS, infertility, pregnancy complications, gestational diabetes and fetal pregnancy complications.

Natural solutions for PCOS

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